In the heart of Niagara-on-the-Lake, 2005 York Road presents an exceptional Portofino-inspired estate offering over 7,500 sqft of refined living space. Backing onto the protected greenspace of the Escarpment, this residence blends architectural distinction, modern innovation, and a serene resort-style setting. The home features 5 bedrooms, including a main-floor primary suite, 4 bathrooms, oversized garages, soaring ceilings and an open-concept layout filled with natural light. Expansive European luxury aluminum windows, including a premium Reynaers system by VIIU, connect the interior seamlessly to the surrounding landscape. The chef's kitchen features top-of-the-line Thermador appliances, an oversized island, quartz countertops and custom cabinetry built for entertaining and everyday living. Privately tucked within its own wing, the main-floor primary suite is a true retreat, with heated floors, a steam shower, spa-inspired ensuite finishes and direct access to the backyard oasis. A striking staircase with glass railings leads to the upper loft, where 2 additional bedrooms, flex space, a full bath, second laundry, and a balcony with sweeping landscape views add exceptional functionality. The finished lower level includes a walkout to the backyard, offering future potential for a theatre, gym or entertaining space. Thoughtful upgrades include in-floor heated bathrooms, power shades, smart-home tech, a Generac backup generator, and a flat roof with heat tracers. Outdoors, the landscaped grounds feel like a private retreat, with an inground pool, hot tub, covered patio, outdoor kitchen and gas fireplace. This luxury-certified residence represents the pinnacle of modern living in Canada's most coveted location. Luxury Certified.